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製品番号: HY-145422

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KIRA9

KIRA9 is a potent IRE1 inhibitor (IC₅₀=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis.

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CAS 番号: 2922507-65-9
分子式: C₂₇H₂₇F₃N₆O₃S
分子量:572.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

KIRA9 構造式

CAS 番号: 2922507-65-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

KIRA9 is a potent IRE1 inhibitor (IC₅₀=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis^[1].

IC₅₀ & Target

IC₅₀: 4.8 μM (IRE1) in INS-1 cells^[1]

体外実験

KIRA9 (0-30 μM; 2 hours) blocks the autophosphorylation induced by conditional overexpression of IRE1α in INS-1 cells (IC₅₀=4.8 μM)^[1].
KIRA9 (20 μM; 2 hours) reduces the mRNA expression of Bloc1s1, Ins1 and Ins2 in INS-1 cells^[1].
KIRA9 (20 μM; 2 hours) blunts IRE1α-dependent decay (RIDD) in ER-stressed INS-1 cells^[1].
KIRA9 (20 μM; 1 hour) markedly reduces the generation of cleaved caspase-3 and shows significant cytoprotective efficacy^[1].
KIRA9 (0-20 μM; 3 days) reduces XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:

INS-1 cells^[1]
Concentration:

20 μM
Incubation Time:

1 hour
Result:

Markedly reduced the generation of cleaved caspase-3 and showed significant cytoprotective efficacy.

Cell Differentiation Assay

Cell Line:

Mouse splenocytes (LPS-treated)^[1]
Concentration:

0, 1.25, 2.5, 5.0, 10 and 20 μM
Incubation Time:

3 days
Result:

Reduced XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner.

Related Protocols :

化学情報

CAS 番号 2922507-65-9
分子量 572.60
分子式 C₂₇H₂₇F₃N₆O₃S
SMILES

O=S(NC1=CC=C(OC2=NC=CC=C2C3=CC=NC(N[C@@H]4CNCCC4)=N3)C5=C1C=CC=C5)(CCC(F)(F)F)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021;17(11):1148-1156. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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