Komaroidine
Komaroidine is a bactericidal agent. Komaroidine induces reactive oxygen species (ROS) bursts in bacterial cells, disrupts antioxidant enzyme function and redox homeostasis, increases membrane permeability, and triggers bacterial apoptosis. Komaroidine suppresses bacterial burden within infected plant tissues.Komaroidine exhibits broad-spectrum antibacterial activity against phytopathogenic bacteria including Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Pseudomonas syringae pv. actinidiae. Komaroidine can be used for the research of rice bacterial leaf blight.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 6649-76-9
- 分子式: C14H18N2
- 分子量:214.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Komaroidine (compound B2) potently inhibits Xoo, Xac, and Psa with EC50 values of 1.12 μg/mL, 4.85 μg/mL, and 20.08 μg/mL, respectively[1].
Komaroidine (12.5-50.0 μg/mL; 15 h) induces dose-dependent ROS accumulation in Xoo cells, with a 4.1-fold increase at 50.0 μg/mL[1].
Komaroidine (3.125-50.0 μg/mL) disrupts antioxidant enzyme activity in Xoo cells, with complete SOD inactivation and declining CAT activity at concentrations ≥12.5 μg/mL[1].
Komaroidine (25.0 μg/mL) synergistically enhances Xoo sensitivity to 0.05 mM H2O2, completely suppressing bacterial growth[1].
Komaroidine (12.5-50.0 μg/mL; 15 h) induces dose-dependent apoptosis in Xoo cells, with a 56.90% total apoptotic rate at 50.0 μg/mL, and increases membrane permeability in Xoo cells in a dose-dependent manner[1].
Komaroidine (compound B2) (25.0 μg/mL; 15 h) alters the transcriptome of Xoo PXO99A cells, affecting metabolic, stress, and apoptosis-related pathways[1].
Komaroidine (compound B2) (200 μg/mL; pot experiment application) exhibits superior in vivo control efficacy against rice bacterial leaf blight (BLB) by significantly reducing bacterial burden in infected tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 6649-76-9
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分子量 214.31
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分子式 C14H18N2
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SMILES
CCCC(NCC1)C2=C1C3=CC=CC=C3N2
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Liu HW, et al. Natural product scaffold-based bactericide discovery: novel β-carboline derivatives as potent reactive oxygen species inducers for crop disease control. Pest Manag Sci. Published online January 10, 2026. [Content Brief]
[2]. Tulyaganov, et al. Alkaloids from plants of the genus Nitraria. Chem Nat Compd 42, 198-200 (2006).
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Komaroidine 関連分類
HY-N18435 関連分類
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- Komaroidine
- 6649-76-9
- Bacterial
- Reactive Oxygen Species (ROS)
- reactive oxygen species
- Nitraria komarovii
- rice bacterial leaf blight
- phytopathogenic bacteria
- Nitraria schoberi
- Pseudomonas syringae pv. actinidiae
- bacterial apoptosis
- Xanthomonas axonopodis pv. citri
- redox homeostasis
- Xanthomonas oryzae pv. oryzae
- Inhibitor
- inhibitor
- inhibit