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製品番号: HY-123707

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KPU-300

KPU-300 (compound 6b) is a tubulin inhibitor. KPU-300 has potent cytotoxicity with an IC₅₀ value of 7.0 nM against HT-29 cells.

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CAS 番号: 1620692-60-5
分子式: C₂₄H₁₇N₃O₃
分子量:395.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KPU-300 構造式

CAS 番号: 1620692-60-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

KPU-300 (compound 6b) is a tubulin inhibitor. KPU-300 has potent cytotoxicity with an IC₅₀ value of 7.0 nM against HT-29 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14.2 nM Compound: 6b, KPU-300	Cytotoxicity against human A549 cells after 48 hrs by WST8 assay Cytotoxicity against human A549 cells after 48 hrs by WST8 assay	[PMID: 25313318]
BXPC-3	IC₅₀	6.27 nM Compound: 2	Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine B assay	[PMID: 29571653]
BXPC-3	IC₅₀	6.3 nM Compound: KPU-300	Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32278711]
HeLa	IC₅₀	5.4 nM Compound: 6b, KPU-300	Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay	[PMID: 25313318]
HT-29	IC₅₀	7 nM Compound: 6b, KPU-300	Cytotoxicity against human HT-29 cells after 48 hrs by XTT/PMS assay Cytotoxicity against human HT-29 cells after 48 hrs by XTT/PMS assay	[PMID: 25313318]
HT-29	IC₅₀	7 nM Compound: KPU-300	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 32278711]

化学情報

CAS 番号 1620692-60-5
分子量 395.41
分子式 C₂₄H₁₇N₃O₃
SMILES

O=C(/C(NC/1=O)=C/C2=CC=CC(C(C3=CC=CC=C3)=O)=C2)NC1=C/C4=NC=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yoshiki Hayashi, et al. Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure. ACS Med Chem Lett. 2014 Jul 23;5(10):1094-8. [Content Brief]

Calculators

モル濃度計算機

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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