MB-VC-MGBA
MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 932744-62-2
- 分子式: C56H65ClN12O10
- 分子量:1101.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
Duocarmycins |
化学情報
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CAS 番号 932744-62-2
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分子量 1101.64
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分子式 C56H65ClN12O10
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SMILES
ClC[C@H](C1)C(C2=CC=CC=C2C(OC(N(CC3)CCN3C)=O)=C4)=C4N1C(C5=CC6=CC(NC(C(C=C7)=CC=C7NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NCCNC(CCCN(C8=O)C(C=C8)=O)=O)=O)=O)=O)=CC=C6N5)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MB-VC-MGBA 関連分類
HY-136289 関連分類
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