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製品番号: HY-187583

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MOA-stilbene

MOA-stilbene is an inhibitor targeting mitochondrial complex III, with fungicidal and insecticidal activities. MOA-stilbene binds to the Qo center of cytochrome b (i.e., the ubiquinol oxidation site, center o), blocking electron transport and inhibiting mitochondrial cellular respiration, thereby reducing the production of reactive oxygen species. MOA-stilbene binds to the Qi center of the chloroplast b6f-complex, inhibiting the reoxidation of reduced bH and bL hemes, the reverse electron transfer from cytochrome c + c1 and ISP to bH and bL, and the electron transfer from bH to bL.

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CAS 番号: 103455-29-4
分子式: C₁₉H₁₈O₃
分子量:294.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MOA-stilbene 構造式

CAS 番号: 103455-29-4

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Oxidative StressBacterial InfectionMitochondrial FunctionMitochondrial Oxidative Phosphorylation

Oxidative Stress

In COS-7 cells and SMP, MOA-stilbene (1 μM; 1 h) produces hydrogen peroxide levels similar to control values under basal conditions; however, in glucose-supplemented COS-7 cells, MOA-stilbene substantially decreases the rate and extent of hydrogen peroxide production, especially in the presence of C6-ceramide^[1].

Bacterial Infection

MOA-stilbene is a potent inhibitor of mitochondrial respiration in bovine heart mitochondria, exhibiting an I₅₀ of 0.04 mM^[2].
In bovine SMP, MOA-stilbene (5 mM) in combination with antimycin causes less inhibition of succinate-induced b heme reduction than the combination of antimycin and myxothiazol^[3].

Mitochondrial Function

Mitochondrial Oxidative Phosphorylation

MOA-stilbene inhibits complex III from yeast, Botrytis, fly, rat, and corn with pI₅₀ values of 7.3, 7.4, 7.8, 7.6, and 6.3, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

ROS/oxidative-stress fluorescent staining

化学情報

CAS 番号 103455-29-4
分子量 294.34
分子式 C₁₉H₁₈O₃
SMILES

COC(/C(C1=C(C=CC=C1)/C=C/C2=CC=CC=C2)=C/OC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Degli Esposti M, et al. Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide-induced apoptosis. FEBS letters. 1998 Jul 03;430(3):338-42.

[2]. Zakharychev V V, Kovalenko L V. Natural compounds of the strobilurin series and their synthetic analogues as cell respiration inhibitors[J]. Russian chemical reviews, 1998, 67(6): 535-544.

[3]. Matsuno-Yagi A, Hatefi Y. Ubiquinol-Cytochrome c Oxidoreductase: THE REDOX REACTIONS OF THE BIS-HEME CYTOCHROME b IN UBIQUINONE-SUFFICIENT AND UBIQUINONE-DEFICIENT SYSTEMS (∗)[J]. Journal of Biological Chemistry, 1996, 271(11): 6164-6171.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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