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製品番号: HY-115499A

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MPC-0767 free base

MPC-0767 free base is an orally active prodrug of Hsp90 inhibitor. MPC-0767 free base undergoes rapid biotransformation to the parent Hsp90 inhibitor MPC-3100 via enzyme-mediated luminal cleavage. MPC-0767 free base is applicable to the research of refractory and recurrent cancers.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1310540-31-8
分子式: C₂₅H₃₀BrN₇O₅S
分子量:620.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MPC-0767 free base 構造式

CAS 番号: 1310540-31-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

MPC-0767 free base mesylate salt has a half-life of <2 min in mouse plasma, 300 min in monkey plasma, 149 min in human plasma, and 145 min in pH 7.4 phosphate buffer^[1].
MPC-0767 free base mesylate salt has a half-life of <2 min in mouse liver microsomes and 2 min in human liver microsomes, with no difference observed between assays run with or without NADPH^[1].
MPC-0767 free base mesylate salt is highly stable in simulated gastric fluid but undergoes rapid conversion in pancreatin-containing simulated intestinal fluid with a half-life of 22 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

MPC-0767 free base mesylate salt (p.o.; 265 mg/kg; single dose) exhibits superior pharmacokinetic properties^[1].

MPC-0767 free base mesylate salt (p.o.; 265 mg/kg) exhibits comparable efficacy in the N-87 xenograft tumor model, inducing a 46% reduction in tumor volume without causing body weight loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1310540-31-8
分子量 620.52
分子式 C₂₅H₃₀BrN₇O₅S
SMILES

C[C@H](N)C(O[C@@H](C)C(N(CC1)CCC1CCN2C3=NC=NC(N)=C3N=C2SC4=C(Br)C=C(OCO5)C5=C4)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kim SH, et al. Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100. Bioorganic & medicinal chemistry letters. 2015 Nov 15;25(22):5254-7. [Content Brief]

[2]. Gomez-Monterrey I, et al. Heat shock protein 90 inhibitors as therapeutic agents. Recent patents on anti-cancer drug discovery. 2012 Sep;7(3):313-36. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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