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製品番号: HY-106111

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Nafagrel

Name: Nafagrel
Brand: MedChemExpress
SKU: HY-106111
Availability: PreOrder

(別名: DP-1904 free acid)

Nafagrel (DP-1904 free acid) is a Thromboxane A₂ synthase inhibitor. Nafagrel inhibits the production of Thromboxane A₂ and increases the production of Prostaglandin I₂ (HY-A0126A). Nafagrel prevents thrombotic material accumulation in acute arterial thrombosis models. Nafagrel can be used in research on peripheral vascular disease, restenosis after PTCA, and lupus nephritis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 97901-21-8
分子式: C₁₅H₁₆N₂O₂
分子量:256.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nafagrel 構造式

CAS 番号: 97901-21-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Prostaglandin Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

Lipid Inflammatory MediatorsLocal Vascular RegulationOthers

Lipid Inflammatory Mediators

Local Vascular Regulation

DP-1904 (0.1 μM-1 mM; 2 h) completely suppresses TXB₂ production and dramatically increases 6-keto-PGF_1α production from human umbilical vein EC and platelets stimulated by HA-IgG in a coculture system, acting as a TXA₂ synthetase inhibitor^[3].

Others

Nafagrel inhibits thromboxane synthase as an imidazole derivative^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[3]

Cell Line:

Human umbilical vein endothelial cells and human platelets
Concentration:

10^-3, 10^-4, 10^-5, 10^-6, 10^-7 M
Incubation Time:

2 h
Result:

Suppressed TXB2 production at 10^-3 to 10^-6 M to levels similar to controls.
Increased 6-keto-PGF1α production at 10^-4 to 10^-7 M.
Decreased the TXB2/6-keto-PGF1α ratio at all concentrations.

体内実験

Local Vascular Regulation

Nafagrel inhibits the accumulation of thrombotic material in a rat model of acute arterial thrombosis, whereas ASA is ineffective^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

化学情報

CAS 番号 97901-21-8
分子量 256.31
分子式 C₁₅H₁₆N₂O₂
SMILES

O=C(O)C1=CC=C2C(=C1)CCC(C2)CN3C=NC=C3
別名

DP-1904 free acid
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Geiger J, et al. Inhibitors of platelet signal transduction as anti-aggregatory drugs. Expert opinion on investigational drugs. 2001 May;10(5):865-90. [Content Brief]

[2]. Herrman J P R, et al. Pharmacological approaches to the prevention of restenosis following angioplasty: the search for the Holy Grail?(Part I)[J]. Drugs, 1993, 46(1): 18-52.

[3]. Kaneko N, et al. Production of thromboxane A2 and prostaglandin i2 affected by interaction of heat aggregated IgG, endothelial cells, and platelets in lupus nephritis. The Journal of rheumatology. 2002 Oct;29(10):2106-13.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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