Nafagrel hydrochloride
Nafagrel hydrochloride is a Thromboxane A2 synthase inhibitor. Nafagrel hydrochloride inhibits the production of Thromboxane A2 and increases the production of Prostaglandin I2 (HY-A0126A). Nafagrel hydrochloride prevents thrombotic material accumulation in acute arterial thrombosis models. Nafagrel hydrochloride can be used in research on peripheral vascular disease, restenosis after PTCA, and lupus nephritis.
For research use only. We do not sell to patients.
- CAS No.: 97901-22-9
- Formula: C15H17ClN2O2
- Molecular Weight:292.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Nafagrel hydrochloride inhibits thromboxane synthase as an imidazole derivative[1].
DP-1904 (0.1 μM-1 mM; 2 h) hydrochloride completely suppresses TXB2 production and dramatically increases 6-keto-PGF1α production from human umbilical vein EC and platelets stimulated by HA-IgG in a coculture system, acting as a TXA2 synthetase inhibitor[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human umbilical vein endothelial cells and human platelets
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Concentration:10^-3, 10^-4, 10^-5, 10^-6, 10^-7 M
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Incubation Time:2 h
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Result:Suppressed TXB2 production at 10^-3 to 10^-6 M to levels similar to controls.
Increased 6-keto-PGF1α production at 10^-4 to 10^-7 M.
Decreased the TXB2/6-keto-PGF1α ratio at all concentrations.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 97901-22-9
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Molecular Weight 292.76
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Formula C15H17ClN2O2
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SMILES
OC(C1=CC=C(CC(CN2C=CN=C2)CC3)C3=C1)=O.Cl
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Synonyms
DP-1904
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nafagrel hydrochloride Related Classifications
HY-106111A Related Classifications
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Keywords
- Nafagrel
- 97901-22-9
- DP-1904
- DP1904
- DP 1904
- Prostaglandin Receptor
- prostaglandin endoperoxides
- thromboxane A2
- prostaglandin I2
- thromboxane A2 synthase inhibitor
- cytochrome P450 enzyme thromboxane synthase
- endothelial cell and platelet coculture systems
- prostaglandin H2
- acute arterial thrombosis models
- heat-aggregated IgG
- lupus nephritis
- Inhibitor
- inhibitor
- inhibit