NCGC-023

NCGC-023 potently inhibits purified LATS1 and LATS2 proteins in cell-free biochemical assays, with IC₅₀ values of 14.1 nM and 14.7 nM, respectively^[1].
NCGC-023 (1 hour) engages and inhibits LATS1 and LATS2 in HEK293 cells, with IC₅₀ values of 367 nM and 57 nM, respectively^[1].
NCGC-023 (4 hours) activates Yap-mediated gene expression in HepG2 human hepatocellular carcinoma cells^[1].
NCGC-023 (3 μM; 48 hours) induces substantial nuclear localization of Yap protein in human jejunal enteroid line J2^[1].
NCGC-023 (1-3 μM; 24 hours prior to irradiation) significantly improves clonogenicity and preserves viability of human jejunal enteroid lines J2 and J3 exposed to 4 or 6 Gy X-rays^[1].
NCGC-023 (1-3 μM; 24 hours) does not induce aberrant growth or morphological changes in unirradiated human jejunal enteroid lines J2 and J3^[1].
NCGC-023 (1-3 μM; 24 hours prior to irradiation) significantly improves clonogenicity of control mouse colonic organoids exposed to 6 Gy X-rays^[1].
NCGC-023 (1-3 μM; 24 hours) does not promote growth of unirradiated Trp53 KO or Apc KO mouse colonic organoids, and decreases clonogenicity of Trp53 KO organoids at 3 μM^[1].
NCGC-023 (1-3 μM; 24 hours prior to irradiation) decreases clonogenicity of Trp53 KO and Apc KO mouse colonic organoids exposed to 6 Gy X-rays^[1].
NCGC-023 protects human enteroids from high-dose radiation-induced death^[2].
NCGC-023 does not promote oncogenesis in pre-malignant murine enteroids^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.