NGD 98-2
NGD 98-2 is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 355836-54-3
- 分子式: C19H24F3N3O3
- 分子量:399.41
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | IC50 |
93 nM
Compound: 59, NGD 98-2
|
Inhibition of human CRF-1 receptor expressed in human IMR-32 cells assessed as effect on cAMP production by ELISA in presence of 3 nM CRF
Inhibition of human CRF-1 receptor expressed in human IMR-32 cells assessed as effect on cAMP production by ELISA in presence of 3 nM CRF
|
[PMID: 21618986] |
化学情報
-
CAS 番号 355836-54-3
-
分子量 399.41
-
分子式 C19H24F3N3O3
-
SMILES
CC1=C(C2=CC=C(OC(F)(F)F)C=C2OC)N=C(OC)C(NC(CC)CC)=N1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem. 2011 Jun 23;54(12):4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27. PMID: 21618986. [Content Brief]
[2]. Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. PLoS One. 2013 Sep 6;8(9):e73749. doi: 10.1371/journal.pone.0073749. PMID: 24040053; PMCID: PMC3765344. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NGD 98-2 関連分類
HY-114070 関連分類
Powered by Bioz