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製品番号: HY-105400

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NIP 502

NIP 502 is a pyridazinone derivative with orally active anti-inflammation and anti-immunology effects. NIP 502 can be used for the research of asthma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 108616-42-8
分子式: C₁₄H₁₆ClN₃O₃
分子量:309.75

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NIP 502 構造式

CAS 番号: 108616-42-8

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NIP 502 is a pyridazinone derivative with orally active anti-inflammation and anti-immunology effects. NIP 502 can be used for the research of asthma^[1].

体外実験

NIP 502 (30-300 μM, 5 mins) significantly inhibits FMLP (HY-P0224)-induced superoxide anion production by guinea pig alveolar macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

NIP-502 (3-10 mg/kg, p.o., 1 h before antigen challenge) inhibits the antigen-induced immediate asthmatic response in passively sensitized guinea pigs^[1].
NIP-502 (30 mg/kg, p.o., 1 h before each ovalbumin aerosol inhalation) inhibits the Ovalbumin (HY-W250978)-induced increase in the number of macrophages, eosinophils, and neutrophils in the bronchoalveolar lavage fluid of guinea pigs^[1].
NIP-502 (30-50 mg/kg, p.o., 1 h before antigen challenge) inhibits the passive cutaneous anaphylactic reaction in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 108616-42-8
分子量 309.75
分子式 C₁₄H₁₆ClN₃O₃
SMILES

CCOC1=C(C=CC(CNC2=C(C(NN=C2)=O)Cl)=C1)OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yamamoto A, et al. Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models. Jpn J Pharmacol. 1995 May;68(1):47-55. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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