NU-7163
NU-7163 is an ATP-competitive DNA-PK inhibitor (IC50=0.19 μM; Ki=24 nM). NU-7163 enhances the cytotoxicity of ionizing radiation against the HeLa human tumor cell line in vitro.
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- CAS 番号: 503468-03-9
- 分子式: C18H17NO3
- 分子量:295.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.19 μM
Compound: 48
|
Inhibition of DNA dependent protein kinase isolated from HeLa cells
Inhibition of DNA dependent protein kinase isolated from HeLa cells
|
[PMID: 15658870] |
| HeLa | IC50 |
4.8 μM
Compound: 48
|
Inhibition of mTOR protein isolated from HeLa cells
Inhibition of mTOR protein isolated from HeLa cells
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[PMID: 15658870] |
化学情報
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CAS 番号 503468-03-9
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分子量 295.33
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分子式 C18H17NO3
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SMILES
O=C1C=C(N2CCOC(C2)C)OC3=C1C=CC4=C3C=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Griffin R J, et al. Selective benzopyranone and pyrimido [2, 1-a] isoquinolin-4-one inhibitors of dna-dependent protein kinase: synthesis, structure− activity studies, and radiosensitization of a human tumor cell line in vitro[J]. Journal of medicinal chemistry, 2005, 48(2): 569-585. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NU-7163 関連分類
HY-116621 関連分類
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