PD-168077
Based on 1 publication(s) in Google Scholar
PD-168077 is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
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- CAS 番号: 190383-31-4
- 分子式: C20H22N4O
- 分子量:334.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 PD-168077
MoreDopamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
17 nM
Compound: 6
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Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
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[PMID: 9191952] |
| HEK293 | EC50 |
>10 μM
Compound: 2
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Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
| HEK293 | EC50 |
8.3 nM
Compound: 2
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Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay
Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
| HEK293 | EC50 |
8.3 nM
Compound: 2, PD-168077
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Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR
Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR
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[PMID: 17149874] |
| HEK293 | IC50 |
>10 μM
Compound: 2
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Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
|
[PMID: 16913699] |
In the PD-168077-treated cell, p-CaMKII exhibits a significantly increased clustering at synaptic sites, as indicated by the enhanced colocalization with PSD-95[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 190383-31-4
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分子量 334.41
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分子式 C20H22N4O
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SMILES
O=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
[1]. Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22(5):538-44. [Content Brief]
[2]. Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69(3):813-22. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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