Plusbacin A3
Plusbacin A3 is a cyclic lipodepsipeptide isolated from Pseudomonas sp. PB-6250 that inhibits bacterial cell wall biosynthesis and disrupts membrane integrity. Plusbacin A3 binds lipid intermediates, blocking transglycosylation and lipid intermediate formation in peptidoglycan synthesis. Plusbacin A3 inhibits teichoic acid biosynthesis. Plusbacin A3 exhibits activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci, with low susceptibility to resistance, and is inactive against Gram-negative bacteria. Plusbacin A3 can be used in research on bacterial infections.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 136660-70-3
- 分子式: C50H83N11O20
- 分子量:1158.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Plusbacin A3 exhibits antimicrobial activity with a MIC range of 0.2 to 6.25 μg/mL against S. pyogenes M49 strain NZ131, S. agalactiae strain A909, ATCC 33591, and ATCC 51299, but is inactive against Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853)[2].
Plusbacin A3 (0.78-3.13 μg/mL) exhibits potent antibiotic activity against methicillin-resistant Staphylococcus aureus and VanA-type vancomycin-resistant enterococci with MIC values ranging from 0.78 to 3.13 μg/mL[3].
Plusbacin A3 inhibits N-acetylglucosamine incorporation into staphylococcal cell wall peptidoglycan with an IC50 close to its MIC value[3].
Plusbacin A3 inhibits both nascent peptidoglycan formation and lipid intermediate formation in bacterial cell wall biosynthesis at a site distinct from the Vancomycin (HY-B0671) binding domain[3].
Plusbacin A3 (20 h) exhibits strong antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, with MIC values ranging from 0.78 to 3.13 μg/mL[5].
Plusbacin A3 (30 min) inhibits the incorporation of [14C]GlcNAc into peptidoglycan of Staphylococcus aureus NCTC8325 whole cells with an IC50 of 0.62 μg/mL[5].
Plusbacin A3 (Various concentrations; 60 min) inhibits the formation of lipid intermediates (IC50 = 2.3 μg/mL) and nascent peptidoglycan (IC50 = 0.4 μg/mL) in an in vitro assay using Staphylococcus aureus SRM133 wall-membrane particulate and supernatant fractions[5].
The inhibition of transglycosylation by Plusbacin A3 (0.78 μg/mL; 60 min) in Staphylococcus aureus SRM133 fractions is not suppressed by acetyl-Lys-D-Ala-D-Ala[5].
The antibacterial activity of Plusbacin A3 (5 μg per disk; Overnight) against Staphylococcus aureus NCTC8325 is antagonized by a wall-membrane particulate[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 136660-70-3
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分子量 1158.26
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分子式 C50H83N11O20
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SMILES
O=C1[C@@]2([H])N(CC[C@@H]2O)C([C@H](NC([C@@](NC([C@@H](NC([C@@]3([H])N(C([C@H](NC([C@@](NC(C[C@H](OC([C@](N1)([H])[C@H](O)C(O)=O)=O)CCCCCCCCCCC(C)C)=O)([H])[C@H](O)C)=O)C)=O)CC[C@@H]3O)=O)CCCNC(N)=N)=O)([H])[C@@H](O)C(O)=O)=O)CO)=O
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Structure Classification
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Initial Source
Pseudomonas sp. PB-6250
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Plusbacin A3 関連分類
HY-N21929 関連分類
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Keywords
- Plusbacin A3
- 136660-70-3
- Plusbacin A 3
- Plusbacin A-3
- Bacterial
- peptidoglycan synthesis
- methicillin-resistant Staphylococcus aureus
- teichoic acid biosynthesis
- cell-wall biosynthesis
- lipid intermediates
- Staphylococcus aureus
- vancomycin-resistant Enterococci
- Park's nucleotide
- Gram-positive bacteria
- transglycosylation
- Inhibitor
- inhibitor
- inhibit