Propargyl-PEG3-acid
Based on 1 Customer Validation
Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.14%
- CAS 番号: 1347760-82-0
- 分子式: C10H16O5
- 分子量:216.23
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-42490
N3-PEG3-CH2CH2COOHPROTAC Linker -
HY-W051634
Propargyl-PEG2-amineADC Linker -
HY-130388
Propargyl-PEG5-NHS esterADC/PROTAC Linker -
HY-130481
Propargyl-PEG4-acidPROTAC Linker -
HY-41921
Propargyl-PEG3-alcoholPROTAC Linker -
HY-130504
Propargyl-PEG1-acidPROTAC Linkers -
HY-118764
Propargyl-PEG2-acidPROTAC/ADC Linker -
HY-101157
Propargyl-PEG5-acidADC Linker -
HY-42149
NH2-PEG2-C2-BocPROTAC/ADC Linker -
HY-130442
Mal-PEG2-acidADC Linker -
HY-W040132
Boc-NH-PEG4-CH2CH2COOH -
HY-140193
Amino-PEG4-BocPROTAC Linkers
PROTAC Linkers アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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PEGs |
Non-cleavable Linker |
体外実験
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1347760-82-0
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性状 Liquid (Density: 1.131±0.06 g/cm3)
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分子量 216.23
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分子式 C10H16O5
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Color Colorless to light yellow
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SMILES
O=C(O)CCOCCOCCOCC#C
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別名
プロパルギル-PEG3-カルボン酸
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (462.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
純度とドキュメンテーション
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データシート (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
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- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6247 mL | 23.1235 mL | 46.2471 mL | 115.6176 mL |
| 5 mM | 0.9249 mL | 4.6247 mL | 9.2494 mL | 23.1235 mL | |
| 10 mM | 0.4625 mL | 2.3124 mL | 4.6247 mL | 11.5618 mL | |
| 15 mM | 0.3083 mL | 1.5416 mL | 3.0831 mL | 7.7078 mL | |
| 20 mM | 0.2312 mL | 1.1562 mL | 2.3124 mL | 5.7809 mL | |
| 25 mM | 0.1850 mL | 0.9249 mL | 1.8499 mL | 4.6247 mL | |
| 30 mM | 0.1542 mL | 0.7708 mL | 1.5416 mL | 3.8539 mL | |
| 40 mM | 0.1156 mL | 0.5781 mL | 1.1562 mL | 2.8904 mL | |
| 50 mM | 0.0925 mL | 0.4625 mL | 0.9249 mL | 2.3124 mL | |
| 60 mM | 0.0771 mL | 0.3854 mL | 0.7708 mL | 1.9270 mL | |
| 80 mM | 0.0578 mL | 0.2890 mL | 0.5781 mL | 1.4452 mL | |
| 100 mM | 0.0462 mL | 0.2312 mL | 0.4625 mL | 1.1562 mL |
Propargyl-PEG3-acid 関連分類
HY-126975 関連分類
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