没食子酸プロピル
Based on 2 publication(s) in Google Scholar
Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. Propyl gallate exhibits anti-inflammatory, antitumor and cardioprotective activities.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.74%
- CAS 番号: 121-79-9
- 分子式: C10H12O5
- 分子量:212.20
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Propyl gallate
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
800 μM
Compound: G3
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 23291333] |
| L929 | IC50 |
40 μM
Compound: G3
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Cytotoxicity against mouse L929 cells
Cytotoxicity against mouse L929 cells
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[PMID: 23291333] |
Propyl gallate (100-1600 μM, 24 h) increases the ROS level, and decreases the level of glutathione (GSH)[3].
Propyl gallate (0-1600 μM, 72 h) inhibits the cancer cell growth of Calu-6 and A549 (IC50 about 50 μM and 800 μM at 24 h), arrests the cell cycle at G1 phase, and induces apoptosis through the mitochondrial pathway and cell death receptor pathway[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Calu-6 and A549
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Concentration:0-200 μM
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Incubation Time:72 h
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Result:Arrested the cell cycle at G1 phase.
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Cell Line:Calu-6 and A549
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Concentration:0-800 μM
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Incubation Time:24 h
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Result:Downregulated Bcl-2 levels, upregulated cleaved PARP level.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DCM mouse models[5]
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Dosage:10-300 mg/kg
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Administration:po, 28 days
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Result:Inhibited cardiac enlargement, decreased left ventricular end-diastolic diameter (LVEDD) and increased ejection fraction (EF).
化学情報
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CAS 番号 121-79-9
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性状 Solid
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分子量 212.20
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分子式 C10H12O5
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Color White to off-white
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SMILES
O=C(OCCC)C1=CC(O)=C(O)C(O)=C1
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別名
Propyl gallate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Propyl gallate mitigates diabetic liver injury via suppressing SLC7A11/GPX4-mediated hepatic ferroptosis and modulating gut-liver axis. [Abstract]2026 Mar 22:249:117926. PMID: 41876017 -
Environ Toxicol
High-dose synthetic phenolic antioxidant propyl gallate impairs mouse oocyte meiotic maturation through inducing mitochondrial dysfunction and DNA damage. [Abstract]2023 Aug;38(8):1800-1810. PMID: 37052413
溶剤 & 溶解度
DMSO : 200 mg/mL (942.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (23.56 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (23.56 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (277 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Cui H, et al. Dual effects of propyl gallate and its methylglyoxal adduct on carbonyl stress and oxidative stress. Food Chem. 2018 Nov 1;265:227-232. [Content Brief]
[2]. Wang J, et al. Scavenging of Acrolein by Food-Grade Antioxidant Propyl Gallate in a Model Reaction System and Cakes. J Agric Food Chem. 2019 Aug 7;67(31):8520-8526. [Content Brief]
[3]. Park WH. Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione. Sci Rep. 2024 Mar 5;14(1):5375. [Content Brief]
[4]. Park WH. Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle. Oncol Rep. 2020 Dec;44(6):2783-2791. [Content Brief]
[5]. Du CK, et al., In vivo effects of propyl gallate, a novel Ca(2+) sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation. Life Sci. 2014 Jul 25;109(1):15-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7125 mL | 23.5627 mL | 47.1254 mL | 117.8134 mL |
| 5 mM | 0.9425 mL | 4.7125 mL | 9.4251 mL | 23.5627 mL | |
| 10 mM | 0.4713 mL | 2.3563 mL | 4.7125 mL | 11.7813 mL | |
| 15 mM | 0.3142 mL | 1.5708 mL | 3.1417 mL | 7.8542 mL | |
| 20 mM | 0.2356 mL | 1.1781 mL | 2.3563 mL | 5.8907 mL | |
| 25 mM | 0.1885 mL | 0.9425 mL | 1.8850 mL | 4.7125 mL | |
| 30 mM | 0.1571 mL | 0.7854 mL | 1.5708 mL | 3.9271 mL | |
| 40 mM | 0.1178 mL | 0.5891 mL | 1.1781 mL | 2.9453 mL | |
| 50 mM | 0.0943 mL | 0.4713 mL | 0.9425 mL | 2.3563 mL | |
| 60 mM | 0.0785 mL | 0.3927 mL | 0.7854 mL | 1.9636 mL | |
| 80 mM | 0.0589 mL | 0.2945 mL | 0.5891 mL | 1.4727 mL | |
| 100 mM | 0.0471 mL | 0.2356 mL | 0.4713 mL | 1.1781 mL |
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