PV-DPD-19
PV-DPD-19 is an autoinducer-2 (AI-2) quorum sensing inhibitor. PV-DPD-19 reduces AI-2 production and inhibits the expression of multiple MSCRAMMs. In co-culture systems with Staphylococcus aureus, PV-DPD-19 decreases the production of pyocyanin and Elastase in Pseudomonas aeruginosa. PV-DPD-19 impairs the adhesion ability of Staphylococcus aureus to lung epithelial cells. PV-DPD-19 inhibits biofilm formation of Pseudomonas aeruginosa (MBIC50 = 27 μg/mL) and Staphylococcus aureus (MBIC50 = 35 μg/mL). PV-DPD-19 shows no cytotoxicity in both in vitro lung epithelial cell models and in vivo Galleria mellonella larva models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3112321-20-4
- 分子式: C15H19NO5
- 分子量:293.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
PV-DPD-19 inhibits biofilm formation by *Pseudomonas aeruginosa* (MBIC50 = 27 μg/mL) and *Staphylococcus aureus* (MBIC50 = 35 μg/mL)[1].
PV-DPD-19 significantly reduces the adhesion rate of *Staphylococcus aureus* to human A549 epithelial cells by approximately 30%[1].
PV-DPD-19 (2 mM; overnight, 8 h) significantly reduces AI-2 production in *Staphylococcus aureus* SH1000 as determined by the *Vibrio harveyi* bioluminescence assay[1].
PV-DPD-19 (20-40 μM; 16 h) reduces pyocyanin production in *Pseudomonas aeruginosa* PAO1 in a dose-dependent manner[1].
PV-DPD-19 (3.12-200 μM; 24 h) shows no cytotoxicity against epithelial cell line A549[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human alveolar basal epithelial carcinoma A549 cells
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Concentration:3.12-200 μM
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Incubation Time:24 h
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Result:Maintained cell viability at 100% for all compounds.
Showed no statistically significant reduction in viability.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:larvae (0.2-0.3 g in weight)[1]
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Dosage:1 μM; 100 μM; 200 μM
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Administration:injected into the proleg using a microsyringe; single dose
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Result:Observed 100% survival at 24 hours post-injection for all doses.
Observed 100% survival at 48 hours post-injection for 1 μM and 200 μM doses, and 97% survival for 100 μM dose.
Observed 98% survival at 72 hours post-injection for 1 μM and 200 μM doses, and 97% survival for 100 μM dose.
Showed no significant survival difference compared to untreated controls.
化学情報
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CAS 番号 3112321-20-4
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分子量 293.32
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分子式 C15H19NO5
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SMILES
CC1(C)OC(C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)CO1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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