S-8666
S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 103968-87-2
- 分子式: C11H11Cl2NO5S
- 分子量:340.18
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
化学情報
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CAS 番号 103968-87-2
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分子量 340.18
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分子式 C11H11Cl2NO5S
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SMILES
O=C(C1OC2=C(C1)C=C(S(=O)(N(C)C)=O)C(Cl)=C2Cl)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Higaki K, Nakano M. Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666. Drug Metab Dispos. 1992 May-Jun;20(3):350-5. [Content Brief]
[2]. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. doi: 10.1254/jjp.43.389. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. doi: 10.1254/jjp.43.389. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
S-8666 関連分類
HY-113724 関連分類
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