SC-26196 (Standard)
SC-26196 (Standard) is the analytical standard of SC-26196 (HY-107410). This product is intended for research and analytical applications. SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 218136-59-5
- 分子式: C27H29N5
- 分子量:423.55
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-107410
SC-26196Delta6 Desaturase Inhibitor -
HY-15823
CAY10566SCD1 Inhibitor -
HY-50709
A939572SCD1 Inhibitor -
HY-13070
MK-8245 -
HY-15822
MF-438SCD1 Inhibitor -
HY-101903
BMS-309403FABP4 Inhibitor -
HY-15700
PluriSIn 1Apoptosis Inducer -
HY-14452A
Fatostatin hydrobromideSREBP Activation Inhibitor -
HY-107613
R 59-022DGK Inhibitor -
HY-13077
MK-8245 Trifluoroacetate -
HY-100907
(±)-Acetylcarnitine chlorideLipid Metabolism Intermediate -
HY-101018
Propionyl-DL-carnitine chlorideCarnitine Derivative
生物活性
製品説明
IC50 & Target
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)[1]
化学情報
-
CAS 番号 218136-59-5
-
分子量 423.55
-
分子式 C27H29N5
-
SMILES
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
[1]. Obukowicz MG, et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther. 1998 Oct;287(1):157-66. [Content Brief]
[2]. Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5;9:432. [Content Brief]
[3]. Hargrave-Barnes KM, et al. Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008 Oct;16(10):2245-52. [Content Brief]
[4]. Zhang L, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SC-26196 (Standard) 関連分類
HY-107410R 関連分類
Powered by Bioz