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製品番号: HY-123524

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STAT3-IN-4

STAT3-IN-4 (compound B9) is a STAT3 inhibitor with K_d values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells.

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CAS 番号: 825611-06-1
分子式: C₂₀H₁₃NO₅S
分子量:379.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

STAT3-IN-4 構造式

CAS 番号: 825611-06-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

STAT3-IN-4 (compound B9) is a STAT3 inhibitor with K_d values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells^[1].

STAT アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	63.77 μM Compound: B9	Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MCF7	IC₅₀	133.7 μM Compound: B9	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MDA-MB-231	IC₅₀	13.8 μM Compound: B9	Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MDA-MB-468	IC₅₀	5.1 μM Compound: B9	Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]

化学情報

CAS 番号 825611-06-1
分子量 379.39
分子式 C₂₀H₁₃NO₅S
SMILES

O=S(C1=CC=C(C(C2=C3C=CC=C2)=O)C(C3=O)=C1)(NC4=CC=C(C=C4)O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Huang M, et al. Screening and biological evaluation of a novel STAT3 signaling pathway inhibitor against cancer. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5172-5176. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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STAT3-IN-4

STAT アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

STAT3-IN-4 関連分類

HY-123524 関連分類