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Recent Posts
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Optogenetics: From Light-Gated Ion Channels to Causal NeuroscienceExplore optogenetics through its molecular mechanisms, experimental strategies, research applications, and translational advances.
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がんの脆弱性のマッピング：拡大する合成致死性のランドスケープExplore emerging synthetic lethal vulnerabilities beyond BRCA–PARP and advances in their discovery and prediction through CRISPR screening, organoids, multi-omics, and AI.
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フェロトーシスの代謝制御：鉄、脂質、ポリアミンReview the metabolic regulation of ferroptosis through iron homeostasis, lipid peroxidation and antioxidant defence, and the emerging polyamine–iron buffering axis.
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生命ドメインを超えて保存された抗ウイルス免疫：病原体認識からエフェクター応答まで哺乳類と細菌に共通して保存された抗ウイルス機構について、ウイルス認識や免疫シグナル伝達から、代謝を介した防御、Gasdermin依存性細胞死に至るまでを概観し、自然免疫の進化における意義を探ります。
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細胞老化のミトコンドリア制御：品質管理、自然免疫、代謝・エピジェネティック制御Explore how mitochondrial quality control, inflammatory signaling, and metabolic–epigenetic reprogramming regulate cellular senescence and the SASP, along with strategies to restore mitochondrial homeostasis.
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単一の「ブレーキ」を超えて：腫瘍による免疫チェックポイントネットワークの動的再構築Explore the mechanisms of tumor immune evasion, dynamic checkpoint regulation, and the evolution of mechanism-driven combinations and patient stratification.