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United States

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製品番号: HY-125453

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Symplostatin 1

Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides.

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CAS 番号: 212007-18-6
分子式: C₄₃H₇₀N₆O₆S
分子量:799.12

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Symplostatin 1 構造式

CAS 番号: 212007-18-6

容量

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A10	EC₅₀	0.6 nM Compound: 2	Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence	[PMID: 11473421]
HT-29	IC₅₀	1.5 nM Compound: Symplostatin 1	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 20806908]
KB	IC₅₀	0.15 nM Compound: 2	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11473421]
KB	IC₅₀	0.3 ng/mL Compound: 2	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 9748368]
LoVo	IC₅₀	0.34 nM Compound: 2	Cytotoxicity against human LoVo cells Cytotoxicity against human LoVo cells	[PMID: 11473421]

化学情報

CAS 番号 212007-18-6
分子量 799.12
分子式 C₄₃H₇₀N₆O₆S
SMILES

O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@H]([C@@]3([H])N(CCC3)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)[C@@H](C)CC)=O)=O)=O)OC
Structure Classification
- Others
Initial Source
- Microorganisms
Cyanobacterium Symploca hydnoides
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Harrigan GG, et al. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. J Nat Prod. 1998 Sep;61(9):1075-7. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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