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製品番号: HY-157469

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TNT-i

Name: TNT-i
Brand: MedChemExpress
SKU: HY-157469
Availability: PreOrder

(別名: NPD3064)

TNT-i (NPD3064) is an inhibitor targeting M-Sec. TNT-i inhibits M-Sec-induced tunneling nanotube (TNT) formation reversibly. TNT-i reduces wild-type HIV-1 production in macrophages and M-Sec-expressing T cells. TNT-i shows low cytotoxic effects on macrophages and T cells. TNT-i can be used for the research of HIV-1 infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₈H₂₅BrN₂O₂
分子量:381.31

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

TNT-i 構造式

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HIV アイソフォーム固有の製品をすべて表示 :

体外実験

TNT-i (10 μM; 24 h) potently and reversibly inhibits M-Sec-induced TNT formation in GFP-M-Sec-transfected HeLa cells^[1].
TNT-i (3-10 μM; 3 days) dose-dependently reduces TNT formation in wild-type HIV-1 JRFL-infected human monocyte-derived macrophages, with a 50% reduction observed after 3 days of incubation^[1].
TNT-i (3-10 μM; 3 days) reduces wild-type HIV-1 production by approximately 50% in human monocyte-derived macrophages, with no effect on Nef-deficient HIV-1 production or MDM cell survival^[1].
TNT-i (10 μM; 4 days) reduces wild-type HIV-1 production by approximately 50% in M-Sec-positive MT-2 T cells, with no effect on Nef-deficient HIV-1 production or MT-2 cell survival^[1].
TNT-i (10 μM; 24 h) does not inhibit Nef-mediated downregulation of cell-surface CD4 or MHC I in 293-CD4 cells, indicating it does not target Nef's core regulatory functions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

性状 Solid
分子量 381.31
分子式 C₁₈H₂₅BrN₂O₂
Color White to off-white
SMILES

CC[C@]1(C2)C[N@@](C(C3=CC(Br)=CC=C3O)[N@@]2C4)C[C@]4(CC)C1O
別名

NPD3064
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hashimoto M, et al. Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages. J Immunol. 2016;196(4):1832-1841. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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