Trenimon
Trenimon is a compound with anti-cancer effects. Trenimon shows mutagenic actions in many species by inducing point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction. Trenimon can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 68-76-8
- 分子式: C12H13N3O2
- 分子量:231.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
2.9 nM
Compound: 2
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In vitro cytotoxicity tested against human chronic leukemia K562 cells
In vitro cytotoxicity tested against human chronic leukemia K562 cells
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[PMID: 9022802] |
Trenimon (0.17 mM) penetrates readily into mouse lymphoma cells in vitro[1]. Trenimon (0.17 nM; 5 min-16 h) time-denpendently reduces the priming activity of DNA[2]. Trenimon (1 nM-10 μM; 10-20 min) leds HeLa cells death after 2 weeks with a dose of 10 μM and dose-dependently suppresses mitosis in cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BR 46 male rats[4]
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Dosage:0.03 mg/kg
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Administration:Intravenous injection; 0.03 mg/kg once per week for 52 weeks
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Result:Showed an cancerogenic effect and 24% animals developed malign tumors, and showed a induction time of the tumors is 16 months.
化学情報
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CAS 番号 68-76-8
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分子量 231.25
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分子式 C12H13N3O2
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SMILES
O=C1C(N2CC2)=C(N3CC3)C(C(N4CC4)=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Linford JH. 2,3,5-Tris-ethylenimino-1,4-benzoquinone (Trenimon): some chemical and biological properties. Chem Biol Interact. 1973 Mar;6(3):149-68. [Content Brief]
[2]. GRUNICKE H, et al. THE EFFECTS OF THE ALKYLATING CYTOSTATIC AGENT, 2,3,5-TRISETHYLENEIMINO-BENZOQUINONE-1,4(TRENIMON), ON THE PRIMING ABILITY OF DNA FROM MOUSE-ASCITES-TUMOR CELLS IN THE RNA-POLYMERASE-SYSTEM. Biochem Biophys Res Commun. 1965 Feb 3;18:319 [Content Brief]
[3]. Wegehaupt S, Sehrbundt HJ. Cytologische Untersuchungen an HeLa-Zellen nach kurzfristigen 2,3,5-Trisathyleniminobenzochinon-1,4-Gaben (Trenimon-R) [Cytologic studies on HeLa cells following short-spaced doses of 2,3,5-trisethyleniminobenzoquinone-1,4 (Tren [Content Brief]
[4]. Obe G, Beek B. Trenimon: biochemical, physiological and genetic effects on cells and organisms. Mutat Res. 1979 Mar;65(1):21-70. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Trenimon 関連分類
HY-105740 関連分類
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