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製品番号: HY-189255

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TrkB-IN-2

TrkB-IN-2 is a TrkB inhibitor. TrkB-IN-2 exhibits anticancer activity against neuroblastoma. TrkB-IN-2 can be used for research on neuroblastoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₄H₂₁FN₄O₆S
分子量:512.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

TrkB-IN-2 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TrkB-IN-2 is a TrkB inhibitor. TrkB-IN-2 exhibits anticancer activity against neuroblastoma. TrkB-IN-2 can be used for research on neuroblastoma^[1].

IC₅₀ & Target

^[1]

TrkB

Trk Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

TrkB-IN-2 (500 nM; 30 min) is among the most effective compounds at suppressing BDNF-induced TrkB phosphorylation in ECP007 cells^[1].
TrkB-IN-2 (100-10000 nM; 30 min) effectively suppresses BDNF-induced TrkB phosphorylation in ECP007 cells in a dose-dependent manner^[1].
TrkB-IN-2 (0.005-100 μM; 72 h) inhibits the growth of COG-N-549 neuroblastoma cells and exhibits cytostatic effects on CUTO-3 cells at concentrations under 10,000 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

ELISA Assay^[1]

View Protocol

Cell Line:

ECP007
Concentration:

500 nM
Incubation Time:

30 min
Result:

Showed the greatest decrease in the ratio of phosphorylated TrkB to total TrkB.

ELISA Assay^[1]

View Protocol

Cell Line:

ECP007
Concentration:

100-10000 nM
Incubation Time:

30 min
Result:

Showed the greatest decrease in the ratio of phosphorylated TrkB to total TrkB.

Cell Viability Assay^[1]

View Protocol

Cell Line:

COG-N-549, ECP005, ECP007, CUTO-3
Concentration:

0.005-100 μM
Incubation Time:

72 h
Result:

Showed growth inhibition in COG-N-549 cells.
Showed cytostatic growth inhibition in CUTO-3 cells at concentrations under 10,000 nM.

化学情報

分子量 512.51
分子式 C₂₄H₂₁FN₄O₆S
SMILES

COC1=CC(C2=NN=C(N2C3=CC=CC=C3)S(=O)(CC(NC4=CC(F)=CC=C4OC)=O)=O)=CC=C1O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Rasmussen S V, et al. Allosteric Inhibition of TrkB Activation as Related to Neuroblastoma by Triazole Bridged Compounds[J]. ACS Chemical Biology, 2026.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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TrkB-IN-2

Trk Receptor アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

TrkB-IN-2 関連分類

HY-189255 関連分類

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Keywords

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