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United States

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製品番号: HY-183389

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Tylogenin

Tylogenin is a Na⁺/K⁺ ATPase inhibitor with an IC₅₀ of 93.3 μM against rabbit-derived targets. Tylogenin inhibits antigen-induced mediator release from rabbit basophils and IgE-dependent histamine release from human leukocytes. Tylogenin exhibits antiallergic activity. Tylogenin can be used in research related to allergic diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 135247-46-0
分子式: C₂₈H₃₈O₁₀
分子量:534.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tylogenin 構造式

CAS 番号: 135247-46-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Tylogenin (1-300 μM; 15-120 min) exhibits time-dependent inhibition of antigen-induced serotonin release from sensitized rabbit basophils in the BDSR assay, with an IC₅₀ of 38.90 μM after 120 min of incubation, and the inhibition rate reaches 92% at a concentration of 300 μM following 120 min of incubation^[1].
Tylogenin (1-300 μM; 4 h) inhibits antigen-induced Histamine (HY-B1204) release from leukocytes of atopic individuals in the LDHR assay, with an IC₅₀ of 48.98 μM^[1].
Tylogenin (5-2000 μM; 1 h) inhibits Na⁺/K⁺ ATPase activity in rabbit renal cortical basolateral membrane vesicles, with an IC₅₀ of 93.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 135247-46-0
分子量 534.60
分子式 C₂₈H₃₈O₁₀
SMILES

C[C@]12[C@@]([C@H](C(CC2)=O)OC(C)=O)([H])[C@H](C[C@]3([H])[C@]1([H])CC[C@@]([C@@H]3OC(C)=O)(C([C@@](C)(O4)OC)=CC4=O)C)OC(C)=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Gnabre, Jean-Noel. Antiallergic activity of Tylophora sylvatica. The University of Arizona.

[2]. Gnabre JN, et al. Antiallergic activity of tylogenin, a novel steroidal compound from Tylophora sylvatica. International journal of immunopharmacology. 1994 Aug;16(8):641-50. [Content Brief]

[3]. Gnabre JN, et al. Tylophora compounds as Na+/K(+)-ATPase inhibitors. Gen Pharmacol. 1993 Sep;24(5):1107-13. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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