ULK1-IN-5
ULK1-IN-5 (Compound D1) is a selective ULK1 inhibitor with an IC50 of 14.91 nM. ULK1-IN-5 functionally inhibits the kinase activity of ULK1. ULK1-IN-5 reduces the phosphorylation level of ATG13. ULK1-IN-5 exerts antiproliferative effects on cervical cancer cells. ULK1-IN-5 is applicable to relevant research on cervical cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C31H42F3N7O3
- 分子量:617.71
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
ULK1 14.91 nM (IC50) |
体外実験
ULK1-IN-5 (starting concentration 100 μM, with serial dilution; enzyme incubation for 10 min) potently inhibits purified ULK1 enzyme, with an IC50 of 14.91 ± 1.06 nM[1].
ULK1-IN-5 inhibits the proliferation of HeLa cells with an IC50 of 0.83 μM, and reduces the level of ULK1-mediated ATG13 phosphorylation in these cells[1].
ULK1-IN-5 (compound D1) (range of concentrations) exhibits low cytotoxicity against normal HUVEC cells, with an IC50 of 11.93 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 617.71
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分子式 C31H42F3N7O3
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SMILES
O=C(OC(C)(C)C)N1CCN(C2=CC(C3CC3)=C(NC4=NC(NCCCN5C(CCCC5)=O)=C(C(F)(F)F)C=N4)C=C2)CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ULK1-IN-5 関連分類
HY-181699 関連分類
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