Umckalin
Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE2 production. Umckalin can be used for the research of chronic inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 43053-62-9
- 分子式: C11H10O5
- 分子量:222.19
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Umckalin (25-400 µM; 72 h) does not reduce viability of B16F10 murine melanoma cells at concentrations up to 200 µM[2].
Umckalin (50-200 µM; 72 h) dose-dependently increases intracellular melanin content in B16F10 murine melanoma cells[2].
Umckalin (50-200 µM; 72 h) dose-dependently enhances tyrosinase activity in B16F10 murine melanoma cells[2].
Umckalin (50-200 µM; 24 h) upregulates TRP-1 and MITF protein expression in B16F10 murine melanoma cells, while having minimal to no effect on tyrosinase and TRP-2 expression[2].
Umckalin (50-200 µM; 24 h) activates the GSK-3β/β-catenin pathway in B16F10 murine melanoma cells by increasing Ser9 phosphorylation of GSK-3β, reducing β-catenin phosphorylation, and increasing total β-catenin levels[2].
Umckalin (50-200 µM; 4 h) suppresses MAPK pathway activity in B16F10 murine melanoma cells by reducing ERK and JNK phosphorylation, while not affecting p38 phosphorylation[2].
Umckalin (50-200 µM; 4 h) activates the PI3K/AKT pathway in B16F10 murine melanoma cells by increasing PI3K and AKT phosphorylationn[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16F10 murine melanoma cells
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Concentration:25; 50; 100; 200; 400 µM
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Incubation Time:72 h
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Result:Showed no cytotoxic effects at concentrations up to 200 µM.
Caused significant cytotoxicity at 400 µM.
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Cell Line:B16F10 murine melanoma cells
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Concentration:50; 100; 200 µM
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Incubation Time:24 h
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Result:Increased TRP-1 protein expression significantly in a dose-dependent manner (p < 0.001 at all concentrations).
Caused a small but significant increase in tyrosinase expression only at 200 µM.
Had no notable effect on TRP-2 expression.
Increased MITF protein expression significantly in a dose-dependent manner.
Increased Ser9 phosphorylation of GSK-3β significantly in a dose-dependent manner.
Increased total β-catenin levels significantly only at 200 µM.
Reduced β-catenin phosphorylation significantly at 200 µM.
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Cell Line:B16F10 murine melanoma cells
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Concentration:50-200 µM
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Incubation Time:4 h
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Result:Reduced ERK phosphorylation significantly in a dose-dependent manner.
Reduced JNK phosphorylation significantly in a dose-dependent manner.
Had no significant effect on p38 phosphorylation.\nIncreased PI3K phosphorylation significantly in a dose-dependent manner.
Increased AKT phosphorylation significantly in a dose-dependent manner.
化学情報
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CAS 番号 43053-62-9
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分子量 222.19
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分子式 C11H10O5
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SMILES
O=C1C=CC2=C(OC)C(OC)=C(O)C=C2O1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Umckalin 関連分類
HY-N8712 関連分類
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