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製品番号: HY-183855

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WF-2421

WF-2421 is an aldose reductase inhibitor with an IC₅₀ of 0.03 μM against rabbit-derived aldose reductase. WF-2421 acts as a non-competitive inhibitor of aldose reductase using dl-glyceraldehyde as the substrate. WF-2421 can be used in the research of diabetic complications (cataract, neuropathy, retinopathy, nephropathy).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 128429-19-6
分子式: C₁₉H₂₀N₂O₈
分子量:404.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

WF-2421 構造式

CAS 番号: 128429-19-6

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

WF-2421 (2 minutes) potently inhibits partially purified rabbit lens aldose reductase with an IC₅₀ of 0.03 μM, acting as an uncompetitive inhibitor relative to DL-glyceraldehyde (HY-128748)^[1].
WF-2421 sodium salt exhibits no antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Trichophyton asteroides, or Candida albicans at 1 mg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 128429-19-6
分子量 404.37
分子式 C₁₉H₂₀N₂O₈
SMILES

O=CNCC(C1=CC(C2=CC(C(C(C(O)=O)NC=O)O)=CC=C2O)=C(O)C=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Nishikawa M, et al. WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea. J Antibiot (Tokyo). 1991;44(2):130-135. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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