Daxdilimab
Based on 1 Customer Validation
Daxdilimab (MEDI7734; VIB7734) is a monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes plasmacytoid dendritic cells and reduces IFN1 production by binding to the plasmacytoid dendritic cell-specific surface molecule ILT7 and recruiting effector natural killer cells. Daxdilimab (MEDI7734; VIB7734) can be used for research on systemic lupus erythematosus, systemic sclerosis, and polymyositis.
For research use only. We do not sell to patients.
- Purity : 97.82%
- CAS No.: 2245966-28-1
- Molecular Weight:144.38 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
ILT7 |
IFN1 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 lambda2
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized LILRA4/ILT-7/CD85g Protein, Human (HEK293, His, HY-P77441) can bind Daxdilimab. The EC50 for this effect is 641.3 ng/mL.
Chemical Information
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CAS No. 2245966-28-1
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Appearance Liquid
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Molecular Weight 144.38 kDa
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Color Colorless to light yellow
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SMILES
[Daxdilimab]
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Synonyms
MEDI7734; VIB7734
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Daxdilimab
- 2245966-28-1
- MEDI7734
- VIB7734
- MEDI 7734
- MEDI-7734
- VIB7734
- VIB 7734
- VIB-7734
- Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
- IFNAR
- immunoglobulin-like transcript 7
- IFN1
- type I interferon
- dermatomyositis
- plasmacytoid dendritic cells
- cutaneous lupus erythematosus
- systemic sclerosis
- systemic lupus erythematosus
- natural killer cells
- ILT7
- Inhibitor
- inhibitor
- inhibit