country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-134980

Copy Link Print Information

LK-980

LK-980 is a cholesterol biosynthesis inhibitor. LK-980 primarily inhibits human sterol Δ7-reductase (DHCR7), and more weakly inhibits sterol Δ14-reductase (DHCR14), sterol Δ24-reductase (DHCR24), and sterol C5-desaturase (SC5DL). LK-980 is slowly metabolized in human primary hepatocytes and does not induce CYP3A4 enzyme activity or mRNA expression. LK-980 can be used in research related to cholesterol metabolism disorders such as hyperlipidemia and atherosclerosis, as well as cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 943250-95-1
Formula: C₁₉H₂₅N₃O
Molecular Weight:311.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LK-980 Chemical Structure

CAS No.: 943250-95-1

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

LK-980 (100 µM; 50 min) did not inhibit HMGCR activity in HepG2 microsomes^[1].
LK-980 (1 µM) was slowly metabolized by human primary hepatocytes, with a half-life of 4.32 h in HH-114 and >6 h in HH-089 and HH-129^[1].
LK-980 (10 µM; 48 h) primarily inhibits DHCR7 in human primary hepatocytes, increasing 7-dehydrocholesterol by 34.16-fold, while slight increases in FF-MAS, desmosterol, and lathosterol indicate weak inhibition of DHCR14, DHCR24, and SC5DL^[1].
LK-980 (10 µM; 12-48 h) does not induce CYP3A4 activity or mRNA in human primary hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 943250-95-1
Molecular Weight 311.43
Formula C₁₉H₂₅N₃O
SMILES

OC(C=1C=NC=CC1)CN2CCN(CCC=3C=CC=CC3)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Acimovic J, et al. Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis. Drug metabolism and disposition: the biological fate of chemicals. 2011 Jan;39(1):39-46.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote