Magnesium fluoride
Based on 1 Customer Validation
Magnesium fluoride is a biochemical reagent. Magnesium fluoride nanoparticles act as an antibacterial and antibiofilm agent with activity against pathogenic bacteria. Magnesium fluoride can be used for the research of bacteria-related infections.
For research use only. We do not sell to patients.
- Purity : 98.62%
- CAS No.: 7783-40-6
- Formula: MgF2
- Molecular Weight:62.30
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Description
In Vitro
Magnesium fluoride nanoparticles (0.0234-1.5 mg/mL; 24 h) inhibit the growth and biofilm formation of Escherichia coli C600 and Staphylococcus aureus FRF1169 in a dose-dependent manner, and completely inhibit the growth and biofilm formation of Staphylococcus aureus at a concentration of 1.5 mg/mL[1].
Magnesium fluoride nanoparticles (1 mg/mL; 4 h) alter the cellular morphology of Escherichia coli C600 and Staphylococcus aureus FRF1169, resulting in rough cell surfaces, cell wall damage, and nanoparticle adhesion to the cell surface[1].
Magnesium fluoride nanoparticles (1 mg/mL; 4 h) localize on the surface and inside the cell membrane of Escherichia coli C600 and Staphylococcus aureus FRF1169 cells, and increase intracellular Mg2+ and F− levels[1].
Magnesium fluoride nanoparticles (1 mg/mL; overnight) interact with chromosomal DNA of Escherichia coli C600 and Staphylococcus aureus FRF1169, increasing the levels of fluorine and magnesium associated with purified DNA[1].
Magnesium fluoride nanoparticles (1 mg/mL; 8 h) disrupt the membrane potential of E. coli C600 and S. aureus FRF1169, reducing the red/green fluorescence ratio of E. coli from 1.242 to 0.45 and that of S. aureus from 6.31 to 1.925[1].
Magnesium fluoride nanoparticles (1 mg/mL; overnight) induce membrane lipid peroxidation in E. coli C600 and S. aureus, increasing the malondialdehyde level to 106.8 nM in E. coli and 72.1 nM in S. aureus[1].
Magnesium fluoride forms a stable complex with the fluoride riboswitch of Thermotoga thermophilic petroleum bacteria[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 7783-40-6
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Appearance Solid
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Molecular Weight 62.30
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Formula MgF2
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Color White to off-white
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SMILES
F[Mg]F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Lellouche J, et al. Antibiofilm activity of nanosized magnesium fluoride. Biomaterials. 2009 Oct;30(30):5969-78. [Content Brief]
[2]. Wedekind JE, et al. Metalloriboswitches: RNA-based inorganic ion sensors that regulate genes. The Journal of biological chemistry. 2017 Jun 09;292(23):9441-9450. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Magnesium fluoride
- 7783-40-6
- Biochemical Assay Reagents
- Bacterial
- Bacillus cereus
- Thermotoga petrophila
- fluoride riboswitches
- biofilm formation
- Staphylococcus aureus FRF1169
- membrane lipid peroxidation
- bacterial chromosomal DNA
- Pseudomonas syringae
- Escherichia coli C600
- bacterial membrane potential
- Inhibitor
- inhibitor
- inhibit