PA1
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1620951-72-5
- Formula: C18H16ClN9O
- Molecular Weight:409.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1620951-72-5
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Molecular Weight 409.83
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Formula C18H16ClN9O
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SMILES
O=C(NC(NC1=CC=C(C=C1)/N=N/C2=CC=CC=C2)=N)C3=NC(Cl)=C(N=C3N)N
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Synonyms
Photoamiloride-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PA1 Related Classifications
HY-125667 Related Classifications
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