PBA-1105b
Based on 1 Customer Validation
PBA-1105b is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105b binds to the ZZ domain of p62, inducing conformational activation and self-oligomerization for autophagy targeting. PBA-1105b is used in research on neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity : 98.01%
- CAS No.: 2941386-60-1
- Formula: C47H64N2O10
- Molecular Weight:817.02
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
PBA-1105b induces the degradation of mutant desminL385P[1].
PBA-1105b is effective against tauP301L in SH-SY5Y cells, demonstrating that AUTOTACs are linker length-insensitive[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2941386-60-1
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Appearance Oil
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Molecular Weight 817.02
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Formula C47H64N2O10
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Color Colorless to light yellow
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SMILES
O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCOCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (244.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nature communications. 2022 Feb 16;13(1):904. [Content Brief]
[2]. Ding Y, et al. Emerging degrader technologies engaging lysosomal pathways. Chemical Society reviews. 2022 Oct 31;51(21):8832-8876. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2240 mL | 6.1198 mL | 12.2396 mL | 30.5990 mL |
| 5 mM | 0.2448 mL | 1.2240 mL | 2.4479 mL | 6.1198 mL | |
| 10 mM | 0.1224 mL | 0.6120 mL | 1.2240 mL | 3.0599 mL | |
| 15 mM | 0.0816 mL | 0.4080 mL | 0.8160 mL | 2.0399 mL | |
| 20 mM | 0.0612 mL | 0.3060 mL | 0.6120 mL | 1.5300 mL | |
| 25 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL | 1.2240 mL | |
| 30 mM | 0.0408 mL | 0.2040 mL | 0.4080 mL | 1.0200 mL | |
| 40 mM | 0.0306 mL | 0.1530 mL | 0.3060 mL | 0.7650 mL | |
| 50 mM | 0.0245 mL | 0.1224 mL | 0.2448 mL | 0.6120 mL | |
| 60 mM | 0.0204 mL | 0.1020 mL | 0.2040 mL | 0.5100 mL | |
| 80 mM | 0.0153 mL | 0.0765 mL | 0.1530 mL | 0.3825 mL | |
| 100 mM | 0.0122 mL | 0.0612 mL | 0.1224 mL | 0.3060 mL |
PBA-1105b Related Classifications
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