RW3
Based on 1 Customer Validation
RW3 (MP196) is a small cationic antimicrobial hexapeptide. RW3 targets the bacterial cytoplasmic membrane and inhibits cellular respiration and cell wall synthesis. RW3 exhibits high bioactivity against Gram-positive bacteria such as Bacillus subtilis 168 (MIC of 2 µg/mL). RW3 causes shrinking of murine erythrocytes. RW3 can be used in antimicrobial and antifungal research.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 359632-11-4
- Formula: C51H69N19O6
- Molecular Weight:1044.22
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
RW3 (16 h) shows decent activity against Gram-positive bacteria like Bacillus subtilis 168 (MIC of 2 µg/mL) and some MRSA/VISA strains, but weak activity against Gram-negative bacteria such as Pseudomonas aeruginosa PA01 (MIC of >64 µg/mL)[1].
RW3 (0.09-200 µg/mL; 72 h) shows no significant cytotoxicity against NRK-52E rat kidney epithelial cells and CCRF-CEM human T-cell lymphoblast cells[1].
RW3 (10 ng-500 µg/mL; 1-24 h) does not induce NF-κB activation in RT4 bladder epithelial cells[1].
RW3 (250-500 µg/mL) causes shrinking of murine erythrocytes at 250 µg/mL and severe morphological changes plus lysis at 500 µg/mL, with 14% and 23% hemolysis respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 359632-11-4
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Appearance Solid
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Molecular Weight 1044.22
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Formula C51H69N19O6
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Color White to off-white
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Sequence
Arg-Trp-Arg-Trp-Arg-Trp-NH2
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Sequence Shortening
RWRWRW-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 25 mg/mL (23.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9577 mL | 4.7883 mL | 9.5765 mL | 23.9413 mL |
| 5 mM | 0.1915 mL | 0.9577 mL | 1.9153 mL | 4.7883 mL | |
| 10 mM | 0.0958 mL | 0.4788 mL | 0.9577 mL | 2.3941 mL | |
| 15 mM | 0.0638 mL | 0.3192 mL | 0.6384 mL | 1.5961 mL | |
| 20 mM | 0.0479 mL | 0.2394 mL | 0.4788 mL | 1.1971 mL |
RW3 Related Classifications
HY-P10281 Related Classifications
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