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Cat. No.: HY-125453

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Symplostatin 1

Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides.

For research use only. We do not sell to patients.

CAS No.: 212007-18-6
Formula: C₄₃H₇₀N₆O₆S
Molecular Weight:799.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Symplostatin 1 Chemical Structure

CAS No.: 212007-18-6

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A10	EC₅₀	0.6 nM Compound: 2	Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence	[PMID: 11473421]
HT-29	IC₅₀	1.5 nM Compound: Symplostatin 1	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 20806908]
KB	IC₅₀	0.15 nM Compound: 2	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11473421]
KB	IC₅₀	0.3 ng/mL Compound: 2	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 9748368]
LoVo	IC₅₀	0.34 nM Compound: 2	Cytotoxicity against human LoVo cells Cytotoxicity against human LoVo cells	[PMID: 11473421]

Chemical Information

CAS No. 212007-18-6
Molecular Weight 799.12
Formula C₄₃H₇₀N₆O₆S
SMILES

O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@H]([C@@]3([H])N(CCC3)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)[C@@H](C)CC)=O)=O)=O)OC
Structure Classification
- Others
Initial Source
- Microorganisms
Cyanobacterium Symploca hydnoides
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Harrigan GG, et al. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. J Nat Prod. 1998 Sep;61(9):1075-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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