Inarigivir
Inarigivir (ORI-9020) is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as a RIG-I agonist to activate cellular innate immune responses.
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- CAS No.: 475650-36-3
- 화학식: C20H26N7O10PS
- 분자량:587.50
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
Target: HBV[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | CC50 |
>1000 μM
Compound: 1
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Cytotoxicity against human HFF cells after 24 hrs by MTT assay
Cytotoxicity against human HFF cells after 24 hrs by MTT assay
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[PMID: 20117930] |
| Vero | CC50 |
>1000 μM
Compound: 1
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Cytotoxicity against african green monkey Vero cells after 24 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 24 hrs by MTT assay
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[PMID: 20117930] |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:100 mg/kg.
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Administration:IP, daily.
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Result:Significantly reduced viral DNA in the liver and shows anti-HBV activity similar ADV positive control.
Chemical Information
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CAS No. 475650-36-3
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Appearance Solid
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분자량 587.50
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화학식 C20H26N7O10PS
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Color White to off-white
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SMILES
NC1=C(N=CN2[C@@H]3O[C@H](COP(O[C@H]4[C@@H](OC)[C@H](N5C=CC(NC5=O)=O)O[C@@H]4CO)(S)=O)[C@@H](O)C3)C2=NC=N1
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Synonyms
ORI-9020; SB-9000
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 200 mg/mL (340.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7021 mL | 8.5106 mL | 17.0213 mL | 42.5532 mL |
| 5 mM | 0.3404 mL | 1.7021 mL | 3.4043 mL | 8.5106 mL | |
| 10 mM | 0.1702 mL | 0.8511 mL | 1.7021 mL | 4.2553 mL | |
| 15 mM | 0.1135 mL | 0.5674 mL | 1.1348 mL | 2.8369 mL | |
| 20 mM | 0.0851 mL | 0.4255 mL | 0.8511 mL | 2.1277 mL | |
| 25 mM | 0.0681 mL | 0.3404 mL | 0.6809 mL | 1.7021 mL | |
| 30 mM | 0.0567 mL | 0.2837 mL | 0.5674 mL | 1.4184 mL | |
| 40 mM | 0.0426 mL | 0.2128 mL | 0.4255 mL | 1.0638 mL | |
| 50 mM | 0.0340 mL | 0.1702 mL | 0.3404 mL | 0.8511 mL | |
| 60 mM | 0.0284 mL | 0.1418 mL | 0.2837 mL | 0.7092 mL | |
| 80 mM | 0.0213 mL | 0.1064 mL | 0.2128 mL | 0.5319 mL | |
| 100 mM | 0.0170 mL | 0.0851 mL | 0.1702 mL | 0.4255 mL |
Inarigivir Related Classifications
HY-101954 Related Classifications
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