RO-7
RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.
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- CAS No.: 1370241-45-4
- 화학식: C24H20F3N3O3S
- 분자량:487.49
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
11.9 μM
Compound: 76; RO-7
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Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
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[PMID: 28118010] |
| MDCK | CC50 |
86.2 μM
Compound: 76; RO-7
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Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
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[PMID: 28118010] |
RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1370241-45-4
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분자량 487.49
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화학식 C24H20F3N3O3S
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SMILES
O=C1N([C@H](C)C(F)(F)F)CN([C@@H]2C3=CC=CC=C3SCC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RO-7 Related Classifications
HY-112684 Related Classifications
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