Neuropeptide Y Receptor
NPY receptor
Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.
Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).
Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.
Neuropeptide Y Receptor Isoform Specific Products
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Neuropeptide Y Receptor Inhibitors
(15)
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Neuropeptide Y Receptor Agonists
(71)
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Neuropeptide Y Receptor Antagonists
(62)
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Neuropeptide Y Receptor Activators
(2)
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Neuropeptide Y Receptor Modulators
(6)
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Neuropeptide Y Receptor Control
(1)
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Neuropeptide Y Receptor 관련 제품 (181)
관련 제품 (181)
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Antibodies (8)
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Neuropeptide Y Receptor Isoform Comparison
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Galanin (swine)
0 ImagesGalanin (swine), a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) is a galanin receptor agonist with pKis of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively.
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NPY1R Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09511NPY1R Human Pre-designed siRNA Set A contains three designed siRNAs for NPY1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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RFRP-1(human) TFA
0 ImagesCat. No.: HY-P1428ARFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.
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Npy5r Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09521Npy5r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy5r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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(Leu31,Pro34)-Peptide YY (human)
0 ImagesCat. No.: HY-P3877CAS No.: 179986-95-9(Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM.
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NPY2R Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09514NPY2R Human Pre-designed siRNA Set A contains three designed siRNAs for NPY2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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(D-Trp32)-Neuropeptide Y (porcine)
0 ImagesCat. No.: HY-P5757CAS No.: 153549-78-1Synonyms: (D-Trp32)-NPY
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BIBO3304 diTFA
0 ImagesCat. No.: HY-107725ACAS No.: 2310085-85-7BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway.
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VU0506013
0 ImagesCat. No.: HY-149593CAS No.: 1207036-87-0VU0506013 is a selective positive allosteric modulator of Y4R (KB = 34.9 nM). VU0506013 can be used in the development of anti-obesity agents targeting Y4R.
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Pancreatic Polypeptide, bovine
0 ImagesCat. No.: HY-P1537CAS No.: 179986-89-1Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.
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R06039-636
0 ImagesCat. No.: HY-186035CAS No.: 2138444-70-7R06039-636 is an agonist of the Neuropeptide S receptor (NPSR) with an EC50 value of 94nM.
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Tiglic acid (Standard)
0 ImagesTiglic acid (Standard) is the analytical standard of Tiglic acid (HY-W012999). This product is intended for research and analytical applications. Tiglic acid is a monocarboxylic unsaturated organic acid. Tiglic acid can be isolated from croton oil. Tiglic acid agonizes FFA2 and upregulates PYY expression. Tiglic acid derivatives have anti-inflammatory activity. Tiglic acid can be used in the research of obesity, diabetes, and inflammatory diseases.
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GEP44
0 ImagesCat. No.: HY-P11043GEP44 is a peptide biased triple agonist targeting Glucagon-like peptide 1 receptor (GLP-1R), neuropeptide Y1 Receptor (Y1-R), and neuropeptide Y2 Receptor (Y2-R). GEP44 induces Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets by counteracting effects of Y1-R and GLP-1R agonism. GEP44 promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 can be used for obesity and type 2 diabetes mellitus research.
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Galanin (1-29)(rat, mouse)
0 ImagesCat. No.: HY-P1132CAS No.: 114547-31-8
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Y1R probe-1
0 ImagesCat. No.: HY-145837CAS No.: 2773476-41-6Y1R probe-1 (Compound 39) is a high-affinity fluorescence probe for the Neuropeptide Y Y1 Receptor. Y1R probe-1 has the potential for the research of cancer disease.
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BVD 10
0 ImagesCat. No.: HY-P1327CAS No.: 262418-00-8BVD 10, a neuropeptide Y (NPY) analogue peptide, is a highly selective NPY Y1 receptor antagonist. BVD10 significantly prevents NPY-induced glutamate increase. BVD 10 can be used for seizure research.
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[Leu31,Pro34]-Neuropeptide Y (human,rat,mouse)
![[Leu31,Pro34]-Neuropeptide Y (human,rat,mouse)](https://file.medchemexpress.com/product_pic/hy-p1323.gif "Click to View [Leu31,Pro34]-Neuropeptide Y (human,rat,mouse) Product Detail")
0 ImagesCat. No.: HY-P1323CAS No.: 132699-73-1[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake.
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NNC0165-1273
0 ImagesCat. No.: HY-P11291NNC0165-1273 is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 blocks Ghrelin-induced cFos expression. NNC0165-1273 reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 can be used in studies related to diet-induced obesity.
