ACSS2-IN-1
ACSS2-IN-1 is a potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of <1 nM. ACSS2-IN-1 inhibits ACSS2 enzymatic activity, blocks the metabolic pathway converting acetate to acetyl-CoA in cancer cells, and thereby suppresses tumor energy metabolism, lipid synthesis and histone acetylation. ACSS2-IN-1 can be used in the research of cancer and hyperproliferative disorders.
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- CAS No.: 2711039-08-4
- 화학식: C27H25ClN6O2
- 분자량:500.98
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
[1]|
ACSS2 < 1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-15 | IC50 |
<1 nM
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Inhibition of ACSS2-mediated lipid synthesis in HCT-15 cancer cells.
Inhibition of ACSS2-mediated lipid synthesis in HCT-15 cancer cells.
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34917239 |
In Vitro
ACSS2-IN-1 (Compound 1) (2-4 h) inhibits endogenous fatty acid synthesis (IC50 <1 nM) and endogenous histone acetylation (IC50 <1 nM) in HCT-15 human colon cancer cells[1].
ACSS2-IN-1 potently inhibits purified ACSS2 with an IC50 of <1 nM[1].
The product (0.2-100 μM; 24 h) shows no genotoxicity in CHO-K1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2711039-08-4
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분자량 500.98
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화학식 C27H25ClN6O2
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SMILES
O=C(C1=CC2=C(CC)C(C(C3=CC=CC=C3)(C4=CC=CC=C4)O)=NN2C=C1Cl)NC5=NN(CC)C=N5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ACSS2-IN-1 Related Classifications
HY-145392 Related Classifications
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