Altemicidin
Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.
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- CAS No.: 125399-82-8
- 화학식: C13H20N4O7S
- 분자량:376.39
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.84 μM
Compound: 9
|
Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell proliferation incubated for 48 hrs by Coulter counter method
Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell proliferation incubated for 48 hrs by Coulter counter method
|
[PMID: 33160760] |
| L1210 | IC50 |
2.12 μM
Compound: 1
|
Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counter analysis
Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counter analysis
|
[PMID: 26035239] |
Chemical Information
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CAS No. 125399-82-8
-
분자량 376.39
-
화학식 C13H20N4O7S
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SMILES
O=C(C[S](N)(=O)=O)N[C@@]1([C@@](CN2C)([H])[C@@](C(C(N)=O)=C2)([H])C[C@@H]1O)C(O)=O
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Synonyms
(-)-Altemicidin
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)