country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-18052

Copy Link Print Information

AM-8553

AM-8553 is a MDM2/p53 inhibitor (K_D: 0.4 nM for MDM2). AM-8553 has anti-tumor activity

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1352064-70-0
화학식: C₂₅H₂₉Cl₂NO₄
분자량:478.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AM-8553 Chemical Structure

CAS No.: 1352064-70-0

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AM-8553 is a MDM2/p53 inhibitor (K_D: 0.4 nM for MDM2). AM-8553 has anti-tumor activity^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>25 μM Compound: 29, AM-8553	Antiproliferative activity against p53 deficient human HCT116 cells assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry Antiproliferative activity against p53 deficient human HCT116 cells assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry	[PMID: 22524527]
HCT-116	IC₅₀	0.2 μM Compound: 29, AM-8553	Antiproliferative activity against human HCT116 cells expressing wild type p53 assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry Antiproliferative activity against human HCT116 cells expressing wild type p53 assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry	[PMID: 22524527]
SJSA-1	ED₅₀	78 mg/kg Compound: 29, AM-8553	Antitumor activity against human SJSA1 cells xenografted in po dosed athymic nude mouse assessed as tumor growth inhibition administered qd after 14 days Antitumor activity against human SJSA1 cells xenografted in po dosed athymic nude mouse assessed as tumor growth inhibition administered qd after 14 days	[PMID: 22524527]
SJSA-1	IC₅₀	0.068 μM Compound: 29, AM-8553	Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation assay in presence of 10% human serum	[PMID: 22524527]
SJSA-1	IC₅₀	0.073 μM Compound: 1, AM-8553	Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation-based HCS assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation-based HCS assay in presence of 10% human serum	[PMID: 25147610]
SJSA-1	IC₅₀	0.76 μM Compound: 29, AM-8553	Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum	[PMID: 22524527]
SJSA-1	IC₅₀	72 nM Compound: 1, AM-8553	Antiproliferative activity against human SJSA1 cells assessed as inhibition of EdU incorporation after 1 hr by Click-iT EdU HCS assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells assessed as inhibition of EdU incorporation after 1 hr by Click-iT EdU HCS assay in presence of 10% human serum	[PMID: 24456472]
SJSA-1	IC₅₀	760 nM Compound: 1, AM-8553	Antiproliferative activity against human SJSA1 cells assessed as induction of p21 gene level by qRT-PCR assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells assessed as induction of p21 gene level by qRT-PCR assay in presence of 10% human serum	[PMID: 24456472]

Chemical Information

CAS No. 1352064-70-0
분자량 478.41
화학식 C₂₅H₂₉Cl₂NO₄
SMILES

O=C(O)C[C@]1(C)C(N([C@@H](CC)[C@@H](O)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bernard D, et al. AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development. J Med Chem. 2012 Jun 14;55(11):4934-5. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기