AP21998
AP21998 is a Fv (mutant FKBP) domain-selective ligand that binds to a single FKBPv. AP21998 disrupts FKBP-mediated oligomerization, blocks the proliferation of transformed myeloid progenitors and facilitates their terminal myeloid differentiation. AP21998 disrupts aggregates of CAD-hM1 receptor fusion protein, allowing receptors to exit the ER and enter the plasma membrane. AP21998 can be used for cancer research.
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- CAS No.: 292606-90-7
- 화학식: C43H59N3O10
- 분자량:777.94
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 292606-90-7
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분자량 777.94
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화학식 C43H59N3O10
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SMILES
O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(NCCCN(C)C)=O)=CC=C2)CCC3=CC(OC)=C(C=C3)OC)=O)[C@H](C4=CC(OC)=C(C(OC)=C4)OC)CC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Sawyer GW, et al. Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system. J Pharmacol Toxicol Methods. 2006 May-Jun;53(3):219-33. [Content Brief]
[2]. Lin CH, et al. Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis. Sci Rep. 2019 Mar 20;9(1):4915. [Content Brief]
[3]. Song GJ, et al. Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling. Mol Endocrinol. 2005 Nov;19(11):2859-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AP21998 Related Classifications
HY-179354 Related Classifications
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