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Cat. No.: HY-182374

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AX8819

AX8819 is a selective dipeptidyl peptidase II (DPP II) inhibitor with an IC₅₀ of 0.88 nM. AX8819 induces caspase-dependent apoptosis. AX8819 exhibits low non-specific toxicity toward proliferating T cells. AX8819 can be used for the research of B cell chronic lymphocytic leukemia.

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CAS No.: 928161-33-5
화학식: C₁₁H₂₁N₃O
분자량:211.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AX8819 Chemical Structure

CAS No.: 928161-33-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

DPP-2

0.88 nM (IC₅₀)

All Dipeptidyl Peptidase Isoforms :

In Vitro

AX8819 potently and selectively inhibits purified DPP II with an IC₅₀ of 0.88 nM, with no measurable activity against other tested DPP family enzymes^[1].
AX8819 (0.88-44 μM) inhibits overexpressed DPP II activity in DPP II-293T HEK cells at all tested concentrations, inhibits endogenous DPP II activity in Jurkat cells at 4.4-44 μM^[1].
AX8819 (0-44 μM; 16 h) exhibits very low non-specific cytotoxicity toward proliferating Jurkat cells at concentrations up to 44 μM^[1].
AX8819 (4.4-44 μM; 4-16 h) induces apaptosis in resting PBMCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

resting PBMCs
Concentration:

4.4, 8.8, 22, 44 μM
Incubation Time:

4, 8, 16 h
Result:

Induces apaptosis in a time- and concentration-dependent manner.

Chemical Information

CAS No. 928161-33-5
분자량 211.30
화학식 C₁₁H₂₁N₃O
SMILES

NCC[C@H](N)C(N1[C@@]2([H])[C@@](CCC2)([H])CC1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Danilova O, et al. Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. Bioorg Med Chem Lett. 2007;17(2):507-510. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AX8819

All Dipeptidyl Peptidase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AX8819 Related Classifications

HY-182374 Related Classifications

Bioz

Keywords

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