BAY 3389934
BAY 3389934 is a selective dual inhibitor of factor IIa and factor Xa, with an IC50 of 4.9 nM for factor IIa and an IC50 of 0.66 nM for factor Xa. BAY 3389934 directly inhibits the activities of factor IIa and factor Xa and regulates the common coagulation pathway. BAY 3389934 exhibits anticoagulant and organ-protective effects. BAY 3389934 can be used in the research of sepsis and coagulopathy.
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- CAS No.: 2915316-40-2
- 화학식: C26H30ClN5O7S2
- 분자량:624.13
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
BAY 3389934 (1 mg/L; 5 h) metabolizes rapidly in rat plasma, shows moderate stability in rabbit, miniature pig and dog plasma, and exhibits the highest stability in human plasma[1].
BAY 3389934 exhibits high hepatic clearance in rats, moderate clearance in dogs, and low clearance in human hepatocytes, and shows moderate plasma protein binding across different species[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White rabbit (Female)[1]
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Dosage:0.1, 0.3, 1, 3 mg/kg/h
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Administration:i.v.; continuous infusion
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Result:Produced significant, dose-dependent antithrombotic efficacy starting at 0.1 mg/kg/h, as measured by reduced thrombus weight.
Resulted in shorter ear bleeding times than unfractionated heparin at doses with comparable antithrombotic effects.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2915316-40-2
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분자량 624.13
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화학식 C26H30ClN5O7S2
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SMILES
CN1C=CN=C1CCOC([C@@H](NS(C2=C(CC)C(N3C([C@@H](O)CC3)=O)=CC=C2)(=O)=O)CNC(C4=CC=C(Cl)S4)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAY 3389934 Related Classifications
HY-172316 Related Classifications
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