Braxlosiran
Based on 1 Customer Validation
Braxlosiran is a component of the AOC reagent Delpacibart braxlosiran (HY-177566), consisting of an siRNA targeting DUX4 (double homeobox protein) and SMCC linker (HY-42360). Delpacibart braxlosiran binds to TfR1. Aberrant expression of the DUX4 protein causes changes in gene expression in muscle cells, which are associated with muscle function loss in facioscapulohumeral muscular dystrophy (FSHD).
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- Purity : 95.00%
- 분자량:13727.00
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
All Antibody-Oligonucleotide Conjugates (AOCs) Isoforms
More
Biological Activity
제품 설명
IC50 & Target
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Oligonucleotide-Linker Conjugates for AOC |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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분자량 13727.00
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Color White to off-white
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SMILES
N/A
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
순도&문서
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Data Sheet (295 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Braxlosiran
- Antibody-Oligonucleotide Conjugates (AOCs)
- Small Interfering RNA (siRNA)
- DUX4-regulated gene expression
- cynomolgus monkey
- transferrin receptor 1
- DUX4 mRNA
- skeletal muscle cells
- HEK293 cells
- facioscapulohumeral muscular dystrophy
- FSHD patient-derived myotubes
- murine
- non-human primate
- Inhibitor
- inhibitor
- inhibit