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Cat. No.: HY-206735

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CDC14A/B-IN-2

CDC14A/B-IN-2, phosphotyrosine mimetic, is a competitive human CDC14A/B phosphatase inhibitor with IC₅₀ values of 10.4 and 11.2 μM, and K_i values of 5.8 and 7.3 μM. CDC14A/B-IN-2 shows at least 20-fold selectivity over other protein tyrosine phosphatases. CDC14A/B-IN-2 can be used for the research of cancer.

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CAS No.: 3048654-21-0
화학식: C₁₃H₉F₂O₄P
분자량:298.18

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDC14A/B-IN-2 Chemical Structure

CAS No.: 3048654-21-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

hCDC14A

10.4 μM (IC₅₀)

hCDC14B

11.2 μM (IC₅₀)

hCDC14A

5.8 μM (Ki)

hCDC14B

7.3 μM (Ki)

In Vitro

CDC14A/B-IN-2 (Compound 9) (10 min) competitively inhibits recombinant human CDC14A and CDC14B phosphatases with IC₅₀ values of 10.4 and 11.2 μM, and K_i values of 5.8 and 7.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3048654-21-0
분자량 298.18
화학식 C₁₃H₉F₂O₄P
SMILES

O=P(O)(C(F)(C1=C2C3=C(C=CC=C3)OC2=CC=C1)F)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Dong J, et al. Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases. J Med Chem. 2024;67(11):8817-8835. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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