Colestilan
Based on 1 Customer Validation
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research.
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- CAS No.: 95522-45-5
- 화학식: (C4H6N2.C3H5ClO)x
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Colestilan (MCI-196) decreases cholesterol levels by bile acid adsorption through the gastrointestinal tract[2].
Colestilan (1 g) binds 2.52 mmol of phosphate at 2-4 mM phosphate concentration and pH = 7.2 in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Colestilan is able to improve hyperphosphataemia in rats with renal failure induced by adenine administration for 4 weeks[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week old Wistar male rats[3]
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Dosage:0.125 or 0.5 g content per 15 g of the feed
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Administration:Oral in feed, 14 days
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Result:Dose dependently decreased blood phosphate and urinary phosphate excretion.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 95522-45-5
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Appearance Solid
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화학식 (C4H6N2.C3H5ClO)x
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Color Off-white to light yellow
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SMILES
CC1=[N+](CC(C)O)C=CN1C.[n].[Cl-]
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Synonyms
MCI-196; Colestimide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
순도&문서
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Locatelli F, et al. Effect of MCI-196 on serum phosphate and cholesterol levels in haemodialysis patients with hyperphosphataemia: a double-blind, randomized, placebo-controlled study. Nephrol Dial Transplant. 2010 Feb;25(2):574-81. [Content Brief]
[2]. Kurihara S, et al. Effect of MCI-196 (colestilan) as a phosphate binder on hyperphosphataemia in aemodialysis patients: a double-blind, placebo-controlled, short-term trial. Nephrol Dial Transplant. 2005 Feb;20(2):424-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Colestilan Related Classifications
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