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Cat. No.: HY-135123

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DC4SMe

DC4SMe, a phosphate proagent of cytotoxic DNA alkylator DC4, can be used in the synthesis of antibody-drug conjugate (ADC). DC4SMe exhibits IC₅₀s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer.

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CAS No.: 615538-47-1
화학식: C₃₅H₃₁ClN₅O₇PS₂
분자량:764.21

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DC4SMe Chemical Structure

CAS No.: 615538-47-1

사이즈

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Duocarmycins

All ADC Payloads Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	IC₅₀	>3000 pM Compound: 38, DC4SMe	Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
HL-60	IC₅₀	1800 pM Compound: 38, DC4SMe	Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
NAMALVA	IC₅₀	2900 pM Compound: 38, DC4SMe	Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
NAMALVA	IC₅₀	30 pM Compound: 38, DC4SMe	Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay	[PMID: 22148292]
Ramos	IC₅₀	1900 pM Compound: 38, DC4SMe	Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay	[PMID: 22148292]
Ramos	IC₅₀	80 pM Compound: 38, DC4SMe	Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay	[PMID: 22148292]

In Vitro

The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 615538-47-1
분자량 764.21
화학식 C₃₅H₃₁ClN₅O₇PS₂
SMILES

O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(OP(O)(O)=O)C7=CC=CC=C67)=O)=C4)C=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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상품명:
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DC4SMe

All ADC Payloads Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DC4SMe Related Classifications

HY-135123 Related Classifications