Desmethyl Levofloxacin
Based on 1 Customer Validation
Desmethyl Levofloxacin is a metabolite of Levofloxacin (HY-B0330). Levofloxacin is a synthetic fluoroquinolone antibiotic that inhibits the supercoiling activity of bacterial DNA gyrase and prevents DNA replication.
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- Purity : 98.61%
- CAS No.: 117707-40-1
- 화학식: C17H18FN3O4
- 분자량:347.35
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
[1]|
Quinolone |
In Vitro
Desmethyl levofloxacin is a degradation product of Levofloxacin formed under acidic conditions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 117707-40-1
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Appearance Solid
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분자량 347.35
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화학식 C17H18FN3O4
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Color White to off-white
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SMILES
O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCNCC4)C(F)=CC1=C23)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 8.33 mg/mL (23.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Siva R, et al. Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. International journal of chronic obstructive pulmonary disease. 2014;9:179-86. [Content Brief]
[2]. Zheng YJ, et al. An integrated approach for detection and characterization of the trace impurities in levofloxacin using liquid chromatography-tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2014 May 30;28(10):1164-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8789 mL | 14.3947 mL | 28.7894 mL | 71.9735 mL |
| 5 mM | 0.5758 mL | 2.8789 mL | 5.7579 mL | 14.3947 mL | |
| 10 mM | 0.2879 mL | 1.4395 mL | 2.8789 mL | 7.1974 mL | |
| 15 mM | 0.1919 mL | 0.9596 mL | 1.9193 mL | 4.7982 mL | |
| 20 mM | 0.1439 mL | 0.7197 mL | 1.4395 mL | 3.5987 mL |
Desmethyl Levofloxacin Related Classifications
HY-135389 Related Classifications
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